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DeCS
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Descriptor English:
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Glucose-6-Phosphate Isomerase
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Descriptor Spanish:
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Glucosa-6-Fosfato Isomerasa
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Descriptor Portuguese:
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Glucose-6-Fosfato Isomerase
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Synonyms English:
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Phosphoglucose Isomerase
Phosphohexose Isomerase
Glucosephosphate Isomerase
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Tree Number:
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D08.811.399.475.200.350
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Definition English:
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An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA. |
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Entry Combination - descr/qualif English:
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Glucose-6-Phosphate Isomerase/deficiency use Anemia, Hemolytic, Congenital Nonspherocytic
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History Note English:
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1998(1965)
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Allowable Qualifiers English:
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Record Number:
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6101
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Unique Identifier:
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D005956
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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